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13 , 14 , 15 , 16 , 17 , 18 A prospective, double-blind trial comparing colchicine and methotrexate in treatment of primary biliary cirrhosis demonstrated equal efficacy in treating pruritus; however, only methotrexate improved liver histology. Colchicine also has been studied for osteoarthritis of the knee, refractory constipation, and postpericardiotomy syndrome at similar doses. 21 One retrospective study comparing colchicine, oxygen, and prednisone with no therapy demonstrated no differences in survival. 54 , 62 Because of the slow elimination of colchicine from the body, intoxication follows a long course. 12 Incorporating a lower dose colchicine into chemotherapeutic regimens may decrease overall toxicities. 53 Although ingestion of colchicine 7 mg has been reported to be lethal to humans, the more typical lethal dose is 65 mg.

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